Week 1 fantasy outlook centers on workload and health. McCaffrey is a must if active, with Seattle yielding solid numbers historically; Cook faces a Ravens run defense that throttled opponents last season; Stevenson remains a core piece with favorable early-season matchups. White’s role could hinge on pass-game usage, while Benson and Allen carry cuff upside behind established starters. Pearsall and Guerendo offer deep-league flex intrigue if further injury news shifts opportunities for SF. Rodriguez Jr. starts with Washington in a challenging spot, and Achane arrives as a high-ceiling option for Miami if fully healthy.

Prime-time Week 1 pits the Bills against the Ravens in Orchard Park with three Bills prop bets catching fantasy eyes. Dawson Knox to score anytime at +500, Keon Coleman at 40+ receiving yards, and James Cook at 60+ rushing yards headline the slate on DraftKings. Allen’s trust in Knox remains a factor, Coleman looks like a Year 2 breakout candidate, and Buffalo’s run game should stay balanced as they open NBC’s SNF slate.

The bets hinge on Knox’s red-zone chemistry with Allen, Coleman’s growing route discipline, and Cook’s capacity to grind out yards behind a cohesive line and a Bills offense that often leans on multi-pronged attack in primetime.

Baltimore visits Buffalo in Week 1’s Sunday Night Football, a marquee clash of two AFC powers with fantasy implications for every line. The betting board leans Ravens (-125) on the moneyline, Ravens -1.5, and a total of 50.5, signaling a competitive, clock-driven battle with tight defenses and mobile quarterbacks at the center.

Key fantasy angles: Andrews rises with Likely out, Cook faces a stout Ravens run defense, Coleman is a sleeper with top red-zone usage, and Dawkins plus Ricard factor into Bills’ and Ravens’ frontline plans. Expect a cautious game with coaching chess moves, and a lean toward the under as both teams limit big plays early.

Buffalo hosts Baltimore in Week 1, a marquee clash of two MVP QBs and top offenses. Buffalo targets tempo with Dalton Kincaid, Keon Coleman, Josh Palmer, and James Cook, while Allen seeks comfort against Baltimore’s defense.

Baltimore counters with Derrick Henry and a rugged front, aiming to slow Buffalo’s pace and force tough, clock-eating drives. The game carries seeding and home-field implications, making early fantasy production pivotal.

Fantasy takeaway: lean Bills pass-catchers and Cook; Kincaid’s role grows with the new weapons, while Baltimore’s run game and Henry may temper upside for Buffalo’s backfield in Week 1.